Primary neuroendocrine tumor of the liver. Histopathology and immunohistochemistry of three cases confirmed by autopsy
DOI:
https://doi.org/10.51481/amc.v45i3.108Keywords:
Hígado, carcinoide, neuroendocrino, inmunohistoquímicaAbstract
A primary hepatic carcinoid tumor (PHCT) is an uncommonfinding. There are few reports of primary hepatic carcinoidtumors,and less confirmed with a complete autopsy. From March ¿2000 to April 2001 we found 3 cases of PHCTin terminal phase with an atypical histologic pattern Eachcase was positive to a wide variety of inmuno histochemical markers . All of them were confirmed by an autopsy.The-se neoplasies can be detected by reliable diagnostic tools such as the urinary excretion of 5 OH indolacetic acids.
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References
Angeletti S,Annibale B ,Marignani M ,Corleto VD . Natural historyof intestinal carcinoids. Ital J Gastroenterol Hepatol 1999; 31 Suppl 2:S108-10.
Shebani KO ,Souba WW ,Finkelstein DM ,Ott MJ . Prognosis and sur-vival in patients with gastrointestinal tract carcinoiod tumors. AnnSurg1999; 229:815-823.
Vinik A ,McLeod MK ,Shapiro B ,Lloyd RV . Clinical features ,diag-nosis and localization of carcinoid tumors and their management. Gas-troenterol Clin North Am 1989;18:865-893.
Cooper MA ,Smith A ,Khalifa M . Carcinoid syndrome from gastroin-testinal carcinoid tumor without distant metastases. J Clin Gastroente-rol 2002; 35 :106-107.
Sano K ,KosugeT ,Yamamoto J ,Makuuchi M . Primary hepatic carci-noid tumors confirmed with long -term follow up after resection. He-patogastroenterology 1999; 46 suppl 28:2547-2550.
Andreola S ,Lombardi L ,Audisio RA ,Makowka L ,Starzl TE ,Van-Thiel DH . A clinicopathologic studyof primary hepatic carcinoidtu-mors . Cancer 1990 ; 65 :1211-1218.
Caplin ME ,Buscombe JR ,Hilson AJ ,Burroughs AK . Carcinoid Tu-mour. Lancet 1998 ; 352 :799-805.
AsakawaT ,Tomioka T ,Abe K ,Kanematsu T. Primary hepatic carcinoidtumor.J Gastroenterol 1999; 34 :123 -127.
Miura K ,Shirasawa H . Primary carcinoid tumor of the liver.Am J ClinPathol 1988; 89:561-564.
Moriura S,Ikeda S ,Gotou S . Hepatic gastrinoma. Cancer 1993; 72:1547-50.
Ali M,Fayemi AO,Braun EV. Malignant apudoma of the liver withsymptomatic intractable hypoglicemia. Cancer 1978; 42:686-692.
Moyana TN ,Xiang J ,Senthilselvan A ,KulagaA . The spectrum of neu-roendocrine differentiation among gastrointestinal carcinoids .ArchPathol Lab Med 2000; 124 :570 -576.
Staren ED,Gould VE,Warren WH,Wool NL,Economou SG. Neuroen-docrine carcinomas of the colon and rectum:A clinicopathologic eva-luation. Surgery 1988; 104:1080-1089.
Travis WD,Gal AA,Colby T. Reproducibility of neuroendocrine lungtumor classification. Hum Pathol 1998; 29:272-279.
Travis WD ,Rush W ,Koss MN . Survival analysis of200 pulmonaryneuroendocrine tumors with clarification of criteria for atypical carci-noid and its separation from typical carcinoid.Am J Surg Pathol 1998;22:934-944.
Travis WD ,Beasley MB ,Thunnissen F ; Brambilla E ,Steele R . Pul-monary atypical carcinoid:Predictors of survival in 106 cases. HumPathol 2000 ; 31 :1255-1265.
Sioutos N, Virta S ,Kessimian N . Pirmary hepatic carcinoid tumor.Anelectron microscopic and immunohistochemical study.Am J Clin Pat-hol 1991; 95:172. 175.
Ronconi L ,Costi R ,Canavese G ,Bordi C . Carcinoid tumor associa-ted with vascular malformation as a cause of massive gastric bleeding.Am J Gastroenterol 1997; 92:2119-2120?
Schwarz RE,Fuller RA ,Chu P. Gastric carcinoid metastatic to the liver.J Clin Oncol 2002,20:2403-2404.
Modlin IM ,Sandor A . An analysis of 8305 cases of carcinoid tumors.Cancer 1997; 79:813-829.
Tomassetti P. Clinical aspects of carcinoid tumours. Ital J GastroenterolHepatol l999; 31 suppl 2:S 143-146.
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