Review of the use of broad spectrum antibiotics in the private hospital setting in Costa Rica
DOI:
https://doi.org/10.51481/amc.v56i4.854Keywords:
Antibiotic, use of drugs, hospitalAbstract
Background: Errors in prescribing broad spectrum antibiotics lead to problems of bacterial resistance, this has decreased the pharmacological options for treating patients, and increased hospitalization stay and mortality.Methods: This study included patients treated at the Clinica Biblica Hospital from September 1st, 2012 to February 28, 2013 that received at least one IV dose of a broad-spectrum antibiotic. A total of 392 clinical records were analyzed. The documents and information required for the analysis of each patient s case was gathered.Results: Intensive Care Medicine and Internal Medicine were largely responsible for prescribing the antibiotics included in this study. In 68% of cases, the first dose was prescribed to hospitalized patients and in 57% of cases other antibiotics were used along with the broad spectrum ones. In 52% of the cases analyzed, a bacterial culture was not performed in order to justify the use of a broad-spectrum antibiotic. Regarding patients that used broad spectrum antibiotics, 15% to 45% had a prior history of allergy to other antibiotics. In 36% of cases the antibiotic strategy was modified during hospitalization.Conclusion: It is necessary to develop a protocol to manage broad spectrum antibiotics in this hospital, in which the criteria to use each antibiotic is described in order to standardize such use.
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References
Monnet DL. Antibiotic development and the changing role of the pharmaceutical industry. Int J Risk Saf Med 2005;17:133-145.
Demain AL. Antibiotics: Natural Products Essential to Human Health. Med Res Rev 2009;29:821-42.
Cars O, Diaz L, Murray M, Nordberg O, Sivaraman S, Stálsby C, et al. Meeting the challenge of antibiotic resistance. BMJ. 2008;337:a1438.
Yoneyama H, Katsumata R. Antibiotic Resistance in Bacteria and Its Future for Novel Antibiotic Development. Biosci Biotechnol Biochem 2006;70:1060-75.
Davies J, Davies D. Origins and Evolution of Antibiotic Resistance. Microbiol Mol Biol Rev 2010;74:417-33.
Freire-Moran L, Aronsson B, Manz C, Gyssens IC, So AD, Monnet DL, et al. Critical shortage of new antibiotics in development against multidrug-resistant bacteria-Time to react is now. Drug Resist Updat 2011;14:118-24.
French GL. The continuing crisis in antibiotic resistance. Int J of Antimicrob Agents 2010;36S3:S3-S7.
Aminov RI. A brief history of the antibiotic era: lessons learned and challenges for the future. Front Microbiol 2010; 1: 1-7.
World Health Organization. Drug and Therapeutics Committees-A Practical Guide. Recuperado el 9 de abril del 2013. En: http://apps.who.int/ medicinedocs /en/d/Js4882e/8.5.html
American Society of Health-System Pharmacist. ASHP guidelines on medication-use evaluation. Recuperado el 9 de abril del 2013. En: http:// www.ashp.org/DocLibrary/BestPractices/FormGdlMedUseEval.aspx.
González B, Ortún V, Martín J, Cabeza A, López A, Díaz JA, et al. Evaluación del uso apropiado de medicamentos en atención primaria ¿Cómo se puede mejorar? Aten Primaria 2002;30:467-471.
Al-Niemat SI, Bloukh DT, Al-Harasis MD, Al-Fanek AF, Slah RK. Drug use evaluation of antibiotics prescribed in a Jordanian hospital outpatient and emergency clinics using WHO prescribing indicators. Saudi Med J 2008;29:743-48.
Martin CA, Armitstead JA, Mynatt RP, Hoven AD. Moving antimicrobial stewardship from restriction to facilitation. Am J Health Syst Pharm 2011;68:109-10.
Bratzler DW, Patchen E, Olsen KM, Perl TM, Auwaerter PG, Bolon MK, et al. Clinical practice guidelines for antimicrobial prophylaxis in surgery. ASHP Therapeutical Guidelines. Surg Infect (Larchmt) 2013;14:73-156.
Benassini M. Introducción a la Investigación de Mercados, un enfoque para América Latina. 1era ed. México: Prentice Hall; 2001.
Management Sciences for Health and World Health Organization. Drug and Therapeutics Committee Training Course. Submitted to the U.S. Agency for
International Development by the Rational Pharmaceutical Management Plus Program. Arlington (VA): Management Sciences for Health; 2007.
Kennedy LA. Drug use evaluation of amphotericin B lipid complex injection following institution of new treatment guidelines at a tertiary teaching medical center. Formulary Journal 2006; Agosto. Recuperado el 19 Marzo 2013. En: http://formularyjournal.modernmedicine.com/news/drug-use-evaluationamphotericin-b-lipid-complex-injection-following-institution-new-treatment-
Brown S, Ostrowsky B. Medication Use Evaluation Template. Oral Azithromycin Utilization Evaluation. Rockville, MD: Agency for Healthcare Research and Quality, 2012. Recuperado el 19 Marzo 2013. En: http:// www.ahrq.gov/professionals/quality-patient-safety/patient-safety-resources/ cdifftoolkit/cdiffl2tools4d.html
The Society for Healthcare Epidemiology of America. Antimicrobial Stewardship: Implementation Tools & Resources. Recuperado el 19 Marzo
En: http://www.shea-online.org/Assets/files/other_papers/Drug_ Use_Evaluable_Form.pdf
Blackburn K. Retrospective, One Year Drug Usage Evaluation of Nesiritide (Natrecor®) in Hospitalized Patients. Wichita (KA): Wichita State University, 2006. Recuperado el 19 Marzo 2013. http://soar.wichita.edu/bitstream
Shekar HS. Drug use evaluation of cephalosporin's in medicine departments at Victoria hospital Bangalore: College of Pharmacy, 2005. Recuperado el 19 Marzo 2013. En: http://119.82.96.198:8080/jspui/ bitstream/123456789/3070/1/shekhar%20hs.pdf
American Society of Health-System Pharmacists. ASHP guidelines on medication-use evaluation. Am J Health-Syst Pharm 1996; 53:1953-5.
Organización Mundial de la Salud. Drug and Therapeutics Committees - A Practical Guide. Virginia: Management Sciences for Health; 2003.
Gilbert DN, Moellering RC, Eliopoulos GM, Chambers HF, Saag MS. The Sanford Guide to Antimicrobial Therapy 2012. 42° Edición. Virgina: Antimicrobial Therapy, Inc; 2012.
Dellit TH, Owens RC, McGowan JE, Gerding DN, Weinstein RA, Burke JP, et al. Infectious Diseases Society of America and the Society for Healthcare Epidemiology of America Guidelines for Developing an Institutional Program to Enhance Antimicrobial Stewardship. Clin Infect Dis 2007; 44: 159-77.
Lutomski DM, LaFollette JA, Biaglow MA, Haglund LA. Antibiotic allergies in the Medical Record. Effect on Drug Selection and Assessment of Validity. Pharmacotherapy. 2008;28:1348-53.
Ramos A, Muñoz E, Santiago A, García E, Manso M, Torralba A, et al. Optimización del tratamiento antibiótico mediante la participación de expertos en antibióticos. An Med Interna 2007; 24: 375-78.
Tunger O, Karakaya Y, Cetin CB, Dinc G, Borand H. Rational antibiotic use. J Infect Dev Ctries. 2009;3:88-93.
Leekha S, Terrell CL, Edson RS. General Principles of Antimicrobial Therapy. Mayo Clin Proc. 2011;86:156-67.
Rodríguez R, Castorena G, González F, Suárez M, Arroyo S, Moncada D, et al. Programa de monitoreo bacteriológico y de regulación de uso de antibióticos. Experiencia en una unidad de cuidados intensivos. Rev Asoc Mex Med Crit y Ter Int 2011; 25: 87-96.
Berild D, Mohseni A, My L, Jensenius M, Holta S. Adjustment of antibiotic treatment according to the results of the blood cultures leads to decrease antibiotic use and costs. J Antimicrob Chemother 2006; 5
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