First case of hemoglobin Köln (codon98 GTG>ATG) in Costa Rica

Authors

  • Walter Cartín Laboratorio de Estudios Especializados e Investigación
  • Carlos Suárez Caja Costarricense del Seguro Social, Hospital Nacional de Niños "Dr. Carlos Sáenz Herrera"
  • Kathia Valverde Caja Costarricense del Seguro Social, Hospital Nacional de Niños "Dr. Carlos Sáenz Herrera"
  • Bertha Valverde Laboratorio de Estudios Especializados e Investigación
  • Evan Jensen Laboratorio de Estudios Especializados e Investigación
  • Gabriela Abarca Caja Costarricense del Seguro Social, Hospital Nacional de Niños "Dr. Carlos Sáenz Herrera"
  • Luis Mora Laboratorio de Estudios Especializados e Investigación
  • Rafael Jiménez Laboratorio de Estudios Especializados e Investigación

DOI:

https://doi.org/10.51481/amc.v52i1.551

Keywords:

Hemoglobin, hemoglobinopathy, hemolytic anemia, Köln

Abstract

Exposure to certain drugs may result in hemolytic anemia with the appearance of Heinz-bodies in red blood cells. This type of hemolytic anemia may occur by simple drug overdosage in absence of any known abnormality, such as in normal persons or in patients with erithroid enzyme defects (e.g. G6PD deficiency) or unstable hemoglobins.1 The present report shows a Heinz-body hemolytic anemia because of an abnormal hemoglobin. High pressure liquid chromatography (HPLC) and molecular analysis confirmed the first case of Hemoglobin Köln in Costa Rica.

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References

Hutchison H.E, Pinkerton P.H, Waters P, Douglas A.S, Lehmann H, Beale D. Hereditary Heinz-body aenemia, thrombocytopenia, and haemoglobinopathie (Hb Köln) in a Glasgow family. BMJ. 1964; 2:1099-1103.

Galacteros F, Loukopoulos D, Fessas P, Kister J, Arous N, Bohn B, et al. Hemoglobin Köln occurring in association with a beta 0 thalasemia: Hematologic and functional consequences. Blood. 1989; 74:496500.

Hoyer J, Kroft S. Color Atlas of Hemoglobin Disorders. A compendium based on proficiency testing. College of American Pathologist 2003.

Allen D, Burgoyne C, Groat J, Smith C.M, White J. Comparison of hemoglobin Köln erythrocyte Membranes With malondialdehydereacted normal erythrocyte membranes. Blood. 1984; 64:1263-1269.

De Furia F, Miller D. Oxygen affinity in hemoglobin Köln disease. Blood. 1972; 39:398-406.

Imai K, Tiendtadakul P, Opartkiattikul N, Luenee P, Winichagoon P, Svasti J, Fucharoen S. Detection of haemoglobin variants and inference of their functional properties using complete oxygen dissociation curve measurements. Br J Haematol. 2001;112:483-487.

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Published

2010-01-01

Issue

Vol. 52 No. 1 (2010): Acta Médica Costarricense Enero-Marzo de 2010

Section

Caso Clínico

License

Copyright (c) 2009 Acta Médica Costarricense

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How to Cite

First case of hemoglobin Köln (codon98 GTG>ATG) in Costa Rica. (2010). Acta Médica Costarricense , 52(1), 40-41. https://doi.org/10.51481/amc.v52i1.551