Metabolic implications of excessive fructose consumption

Authors

  • Viviana Esquivel Solís Universidad de Costa Rica
  • Georgina Gómez Salas Universidad de Costa Rica

DOI:

https://doi.org/10.51481/amc.v49i4.461

Keywords:

fructose, corn syrup, high infructose, obesity, insulin resistance, dyslipidemia

Abstract

During recent years there has been a remarkable increase in the production of foods sweetened sugar substitutes with less caloric value, that are used in dietary programs to lose weight to maintain a healthy weight as well as to offer options for individuals with diabetes or glucose intolerance.

One of the most common sweeteners is high fructose corn syrup, a less expensive sweetener that has a lower postprandial hyperglycemic effect compared to sucrose.

However new research has shown that prolonged consumption of high fructose diet would contribute to the development of chronic diseases such as obesity, diabetes, lipid disorders, metabolic syndrome and cardiovascular diseases.

This paper describes the possible metabolic implications related to different diseases associated with an excessive fructose consumption.

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References

Mehnert H. 1976. Sugar substitutes in the dieabetic diet. Int Z Vitam Ernahrungsforsch Beih 15:295-324.

Basciano H, Federico L, Adeli K. 2005. Fructose, insulin resistance, and metabolic dislipidemia, Nutrition and Metabolism, 2:5.

Havel P. 2005. Dietary fructose: Implications for dysregulation of energy homeostasis and lipid/carbohydrate metabolism. Nutrition Review 63: 133-157

Hein GL, Storey M, White J, Lineback DR. 2005. Highs and Lows of High fructose corn syrup. A Report form the Center fro Food and

Nutrition Policy and Its Ceres Workshop. Nutrition Today 40:253-

Bantle JP. 2006. Is fructose the optimal low glycemic index sweetener? Nestle Nutr Workshop Ser Clin Perform Progamme. 11:83-91

Schorin MD. 2005. High fructose corn syrups. Part 1 and 2. Nutrition Today. 40:248-252.

Putman J. 1999. Food Consumption, prices and expenditures, 19701991. In Economic Research Service Washington DC. US Department of Agricultu

Nelson DL, Cox MM. 2004. Lehninger principles of Biochemistry. 4th Ed. New York: Worth Pusblishers

Bray G, Nielsen S, Popkin B. 2004. Consumption of high-fructose corn syrup in beverages may play the rol in the epidemic of obesity. Am J Clin Nut. 79:537-43

Fornaguera J. y Gómez G. 2004. Bioquímica: la ciencia de la vida-San José, Costa Rica, Editorial Universidad Estatal a Distancia, 340 p.

Benyon S. 1998. Metabolismo y nutrición. Edición en español Harcort Brace de España, S.S, España, 244 p.

Cui XL, Schlesier AM, Fisher EL, Cequeira C, Ferraris RP. 2005. Fructose- induced increases in neonatal rat intestinal fructose transport involve the PI3-kinase/Akt signalling pathway. Am J Physiol Gastrointest Liver Physiol 288:G1310-G1320

Bantle J, Raatz S, Thomas W, Goergopoulos A. 2000. Effects of dietary fructose on plasma in healthy subjects. Am J Clin Nutri 72:1128-34

Dirlewanger M, Schineiter P, Jéquier E, Tappy L. 2000. Effects of fructuose on hepatic glucose metabolism in humans. Am J Physiol Endocrinol Metab, 279:E907-E911

Elliott S, Kein N, Stern J, Teff K, Havel P. 2002. Fructuose, weight gain, and the insulin resistence syndrome. AM J Clin Nutr 76:911-

Kelley GL, Azhar S. 2005. Reversal of high dietary fructose-induced PPAR? suppression by oral administration of lipoxygenase cyclooxygenase inhibitors. Nutrition & Metabolism 2:18

Teff KL, Elliot SS, Tschop M, Kieffer TJ, Rader D, Heiman M, Townsend RR, Keim NL, D'alessio D, Havel PJ. 2004. Dietary fructose reduces circulating insulin and leptin, attenuates postprandial suppression of ghrelin and increases triglycerides in women. J Clin Endocrinol Metab 89:2963-2972.

Kelley GL, Allan G, Azhar S. 2004. High dietary fructose induces a hepatic stress response resulting in cholesterol and lipid dysregulation. Endocrinology 145:548-555.

Musick T, Cymet TC. 2006. Carbohydrate and calories: is not what we use to think. Compr Ther 32:47-50.

Sartorelli DS, Cardoso MA. 2006. Association between dietary carbohydrates and type 2 diabetes mellitus: epidemiological evidence. Arq Bras Endocrinol Metabol 50:415-26.

Rayssiguier Y, Gueux E, Nowacki W, Rock E, Mazur A. 2006. High fructose consumption combined with low dietary magnesium intake may increase the incidence of metabolic syndrome by inducing inflammation. Magnes Res 19:237-43.

Hawkins M, Grabriely I, Wozniak R, Vilcu C, Shamoon H, Rossetti L. 2002. Fructose improves the ability of hyperglycemia per se to regulates glucose production in type 2 diabetes. Diabetes 51:606614.

Ganon MC, Nutall FQ, Westphal SA, Fan S, Ercan-Fang N. 1998. Metabolic response to carbohydrate, high-starch meals compared with moderate carbohydrate low-starch meals in subjects with type 2 diabetes. Diabetes Care 21:1619-1626.

Gross LS, Li L, Ford ES, Liu S. 2004. Increased consumption of refined carbohydrate and the epidemic of type 2 diabetes in the United States : an ecologic assessment. Am J Clin Nutr 19:774-9.

Davail S, Ridea N, Bernardet MD, Guy G, Hoo-Paris R. 2005. Effect of dietary fructose on liver steatosis in overfed mule ducks. Horm Metab Res 37:32-35.

Bizeau ME, Pagliassotti MJ. 2005. Hepatic adaptation to sucrose and fructose. Metabolism Clinical and Experimental. 54:1189-1201.

Bessesen H. 2001. The role of Carbohydrates in Insuline Resistence.

J. Nutr 131:2782S-2786S.

Zammit VA, Waterman IJ, Topping D, Mc Kay G. 2001. Insulin stimulation of hepatic triacylglicerol secretion and the etiology of insuline resistance. J. Nutr 131:2074-2077

Daly M. 2003. Sugars, insulin sensitivity, and the postprandial state. Am J Clin Nutric; 78 (suppl): 865S-72S.

Jürgens H, Haass W, Castañeda T, Schümann A, Koebnick C, Dombrowski F, Otto B, Nawrocki A, Schere P, Spranger J, Ristow M, Joost H, Havel P, Tschöp M. 2005. Consuming fructose-sweetened beverages increases body adiposity in mice. Obesity research 13: 1146-1156.

Wu T, Giovannucci E, Pischon T, Hankinson S, Nader J, Rimn E. 2004. Fructose, glycemic load, and quantity and quality of carbohydrate in relation to plasma C-peptide concentrations in US women. Am J Clin Nutr 80:1043-9.

Walker CG, Zariwala MG, Holness MJ, Sugden MC. 2007. Diet obesity and diabetes: a current update. Clin Sci 112:93-111.

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Published

2007-10-01

How to Cite

Metabolic implications of excessive fructose consumption. (2007). Acta Médica Costarricense , 49(4), 198-202. https://doi.org/10.51481/amc.v49i4.461