The role of nonsteroidal anti-inflammatory drugs in the production of necrotizing fasciitis
DOI:
https://doi.org/10.51481/amc.v44i1.392Keywords:
fasceítis necrotizante, anti-inflamatorios no esteroideos, infección, inmunosupresiónAbstract
Necrotizing fasceiitis, as a severe group A streptococcusinfection generally originating from localized skin infectionsor disruptions has increased worldwide in recent years. Earlydiagnosis is often difficult due to the appearance ofcharacteristic soft tissue changes only late in the course of thedisease. The medical literature was analized to determinea possible associationbetweennon-setroidalanti-inflammatory drugs and necrotizing fasceiitis and possiblefactors involved in necrotizing fasceiitis. Sample sizes of theclinical studiesreviewed were small, non-randomized,without control groups. Thus, no clinical studies showedscientific evidence of a cause and effect relationship betweennon-setroidal anti-inflammatorydrugs andnecrotizingfasceiitis, regardless of the route of administration. Furtherwell-designed clinical trials should be carried out todetermine if there is a possible association between non-setroidal anti-inflammatory drugs and necrotizing fasceítis.
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