Prevalence of vitamin D deficiency in children
DOI:
https://doi.org/10.51481/amc.v63i2.1110Keywords:
children, vitamin D, vitamin D deficiency, prevalence, Costa RicaAbstract
Objective: To determine the prevalence of vitamin D deficiency in children in the South-Central Region of Costa Rica.
Methods: A cross-sectional study was performed with Costa Rican children aged 1-7 years from the South-Central Region of the country belonging to the Nutrition and Education Centers and Children's Nutrition and Comprehensive Care Centers. Serum samples were collected from all participants between August 2014 and May 2016 and stored at -80 ° C. Vitamin D status was assessed by immunoassay on an ARCHITECT Plus i1000 instrument. Descriptive statistics were performed with the SPSS statistical software package (V20, IBM Corp). A value of p˂0.05 was considered significant. Spearman and Pearson correlation were also performed to study association between vitamin D status, anthropometric and hematological variables.
Results: A total of 428 samples were analyzed. According to the cut-off points established by the Endocrine Society, around 4.9% of the children tested presented deficiency, 50.2% had insufficiency and approximately 44% had vitamin D sufficiency. The mean concentration of 25-hydroxyvitamin D in the studied population was 29.7 ng/mL (SD 6.5) in boys and 29.8 ng/mL (SD 7.0) in girls. A high prevalence of hypovitaminosis D (55.1 %) was found, but only 7.9 % of the children presented 25-hydroxyvitamin D ≤ 20 ng/mL. No correlation was found between vitamin D status and any of the evaluated anthropometric or hematological variables.
Conclusions: More than half of the young population presented hypovitaminosis-D. Therefore, in order to remedy this, the recommendation is to supplement with and improve the fortification of vitamin D in widely accessible food in Costa Rica.
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References
Guo Y, Ke H, Liu Y, Fu M, Ning J, Yu L, et al. Prevalence of vitamin D insufficiency among children in southern china. Medicine 2018; 25:1-5.
Saggese G, Vierucci F, Prodam F, Cardinale F, Cetin I, Chiappini E, et al. Vitamin D in pediatric age: Consensus of the Italian Pediatric Society and the Italian Society of Preventive and Social Pediatrics, jointly with the Italian Federation of Pediatricians. Ital J Pediatr 2018; 44:1-40.
Srivastava T, Garg U, Ruiz M, Dai H, Alon US. Serum 25(OH)-vitamin D level in children: Is there a need to change the reference range based on 2011 institute of medicine report?. Clin Pediatr 2011; 52:178-82.
Rusinska A, PÅ‚udowski P, Walczak M, Borszewska-Kornacka MK, Bossowski A, Chlebna-SokóÅ‚ D, et al. Vitamin D supplementation guidelines for general population and groups at risk of vitamin D deficiency in Poland-Recommendations of the Polish society of pediatric endocrinology and diabetes and the expert panel with participation of national specialist. Front Endocrinol 2018; 216:1-21.
Bivona G, Agnello L, Ciaccio M. Vitamin D and immunomodulation: Is it time to change the reference values? Ann Clin Lab Sci 2017; 47:508-10.
Conradie M, Ascott-Evans B. An interesting D-lemma: What is all the excitement about vitamin D? J Endocrinol Metabol Diabetes S AF 2014; 19:63-6.
Lee JY, So T-Y, Thackray J. A Review on Vitamin D Deficiency Treatment in Pediatric Patients. J Pediatr Pharmacol Ther 2013; 18:277-91.
Rathi N, Rathi A. Vitamin D and child health in the 21 st century. Indian Pediatr 2011; 48:619-25.
Jolliffe DA, Greenberg L, Hooper RL, Griffiths CJ, Camargo CA, Kerley CP, et al. Vitamin D supplementation to prevent asthma exacerbations: a systematic review and meta-analysis of individual participant data. Lancet Respir Med 2017; 5:881-90.
Brehm JM, Celedón JC, Soto-Quiros ME, Avila L, Hunninghake GM, Forno E, et al. Serum vitamin D levels and markers of severity of childhood asthma in Costa Rica. Am J Respir Crit Care Med 2009; 179:765-71.
Golden NH, Abrams SA, Daniels SR, Corkins MR, de Ferranti SD, Magge SN, et al. Optimizing bone health in children and adolescents. Pediatrics 2014; 134:1229-43.
German Nutrition Society. New reference values for Vitamin D. Ann Nutr Metab 2012; 60:241-6.
Müller DN, Kleinewietfeld M, Kvakan H. Vitamin D review. J Renin Angiotensin Aldosterone Syst 2011; 12:125-8.
Holick MF. The vitamin D deficiency pandemic: Approaches for diagnosis, treatment and prevention. Rev Endocr Metab Disord 2017; 18:153-65.
Mithal A, Wahl DA, Bonjour JP, Burckhardt P, Dawson-Hughes B, Eisman JA, et al. Global vitamin D status and determinants of hypovitaminosis D. Osteoporos Int 2009; 20:1807-20.
Montero-Arias F, Sedó-Mejía G, Ramos-Esquivel A. Vitamin D insufficiency and asthma severity in adults from Costa Rica. Allergy Asthma Immunol Res 2013; 5:283-8.
Brehm JM, Acosta-Pérez E, Klei L, Roeder K, Barmada M, Boutaoui N, et al. Vitamin D insufficiency and severe asthma exacerbations in Puerto Rican children. Am J Respir Crit Care Med 2012; 186:140-6.
Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, et al. Evaluation, treatment, and prevention of vitamin D deficiency: An endocrine society clinical practice guideline. J Clin Endocrinol Metab 2011; 96:1911-30.
Misra M, Pacaud D, Petryk A. Deficiencia de vitamina D en los niños y su tratamiento: revisión del conocimiento y las recomendaciones actuales. Pediatrics 2008; 66:86-106.
World Health Organization. Nutritional Anaemias : Tools for Effective Prevention. [Internet]. Geneva: WHO; 2017. [cited 2021 June 24]. Avaible from: https://www.who.int/publications/i/item/9789241513067
World Health Organization. Training Course on Child Growth Assessment: module C Interpreting Indicators. [Internet]. Geneva: WHO; 2008. [cited 2019 June 24]. Available from: https://www.who.int/childgrowth/training/module_c_interpreting_indicators.pdf
Ferrari D, Lombardi G, Banfi G. Concerning the vitamin D reference range: Pre-analytical and analytical variability of vitamin D measurement. Biochem Med 2017; 27:1-14.
Sempos CT, Heijboer AC, Bikle DD, Bollerslev J, Bouillon R, Brannon PM, et al. Vitamin D assays and the definition of hypovitaminosis D: results from the First International Conference on Controversies in Vitamin D. Br J Clin Pharmacol 2018; 84:2194-207.
Institute of Medicine. Dietary reference intakes: calcium, vitamin D. Ross AC, Taylor C, Yaktine A, Del Valle editors H, editors. Washington, DC: The National Academies Press; 2011. 1115p
Bauer P, Henni S, Dörr O, Bauer T, Hamm CW, Most A. High prevalence of vitamin D insufficiency in professional handball athletes. Phys Sportsmed 2019; 47:71-7.
Tangpricha V. Vitamin D Supplementation In Obese Africian American Children. J Clin Transl Endocrinol 2018; 12:48-9.
O'Shea L, Bindman AB. Personal health budgets for patients with complex needs. N Engl J Med 2016; 375:1815-7.
Föcker M, Antel J, Ring S, Hahn D, Kanal Ö, Öztürk D, et al. Vitamin D and mental health in children and adolescents. Eur Child Adolesc Psychiatry 2017; 26:1043-66.
Walsh JS, Evans AL, Bowles S, Naylor KE, Jones KS, Schoenmakers I, et al. Free 25-hydroxyvitamin D is low in obesity, but there are no adverse associations with bone health. Am J Clin Nutr 2016; 103:1465-71.
Rich-Edwards JW, Ganmaa D, Kleinman K, Sumberzul N, Holick MF, Lkhagvasuren T, et al. Randomized trial of fortified milk and supplements to raise 25-hydroxyvitamin D concentrations in schoolchildren in Mongolia. Am J Clin Nutr 2011; 94:578-84.
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