Leptin, lipids and overweight in sixth grade schoolchildren from a marginal urban area
DOI:
https://doi.org/10.51481/amc.v45i3.107Keywords:
Leptina, lípidos, sobrepeso, adolescentesAbstract
Introduction: The hormone called Leptine has been associated with several factors of the Metabolic Syndrome, including hypertension, obesity, insulin resistance and high density li-po protein, not only in adults but also in adolescents. In Cos-ta Rica the levels of leptinemia in adolescents and its relationship with obesity and lípids is unknown.
Objective: To describe the leptinemia levels in sixth graders in an urban marginal area, and its association with lipids and overweight.
Material And Methods: Transversal study was carried on inthe year 2001,with a representive sample sixth graders of12Schools of the Area Desamparados 3 (n= 220).Previous written consent of parents and scholars, weight and height was measured and a 12 hour plasma sample was taken toquantify leptine(IRMA,) total cholesterol, HDL- cholesterol and triglicerides; the LDL-col was calculated.
Results:Theleptinemia levels did not follow a normal distribution, so non-parametricanalysis was used.Its range variedfrom a minimum value of 1.0 ng/ml to a maximum value of42.8 ng/ml in males,and from 3.9 ng/ml to 65.2ng/ml in fe-males. The comparisonof quartiles bysex was highly signi-ficant (p <0.0003); having higher levels in females.The plas-ma leptine concentration showeda positive correlation withtheBody MassIndex (BMI) (rs= 0.43,p<5.7E-11) andtri-glicerides (rs= 0.31,p<4.3E-06),but a negative correlationwithHDL-cholesterol(rs -0.20,p <0.002);there was nocorrelation with total cholesterol or LDL- cholesterol.Whenthe correlation was done by sex,the positive correlation wasgiven mainly by the femininesex(rs 0.59,p <1.05E-12) andits wasmoderate. The triglicéridos behavior was similar inboth sexes,not so withthe HDL,where the negative correla-tionwas only found in females (rs -0.40 p <5.1E-06),but It was weak. When the quartiles of leptine were with the children's nutritional status asignificant differenceswas found in both sexes between the categories of normaland ove r weight (p<0.01),and between slender and overweight (<0.05),but not between the slender and nor-mal categories.
Conclusion:The leptinemia values of the scholars were hig-her in the feminine sex,with a relation of 2:1. The correlationof this variable even thoughweak,was positive for BMI andnegative with HDL-cholesterol,especially in the female ado-lescents.Significant differenceswere found between theslender and normal adolescentes and those that were over-weight.The results of this study are coincident with otherstudies in the international literature.
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References
Bray G.A. Health hazards of obesity. Endocrinol Metab Clin NorthAmer 1996; 25:907-919..
Reaven GM. Role of insulin resistance in human disease. Diabetes1988;37:1595-607
Ministerio de Salud, Fascículo 1. Antropometría,Encuesta Nacional deNutrición,Costa Rica 1996
Gumbiner B. The treatment of obesity in type 2 diabetes mellitus PrimCare. 1999 Dec;26(4):869-83. ..
Campbell L,Rossner S. Management of obesity in patients with Type2 diabetes. Diabet Med. 2001 May; 18(5):345-54.
Jiménez MF y Ruíz L. Niveles de glicemia y de hemoglobina glicosi-lada en un grupo de diabéticos nicoyanos. AMC 2001; 43 (suplemen-to 1):15
Laclé A. Perfil del Paciente Diabético Tipo 2 de 55 y Más Años,de unaClínica Periférica de la Caja Costarricense de Seguro Social. AMC1999; 41:46-51.
Coleman DL. Obesity and diabetes:Two mutant genes causing diabe-tes-obesity syndromes in mice. Diabetología 1978; 14:141-8.
Harris RB,Hervey E,Hervey G R. Body composition of lean and obe-se Zucker rats in parabiosis. Int J Obesity 1987; 11:275-83.
Zhang Y,Proenca R,Maffei M,Barone M,Leopold L,Friedman JM.Positional cloning of the mouse obese gene and its human homologue.Nature 1994; 372:425-32.
Halaas J,Gajiwala KS,Maffei M,Cohen SL,Chait BT,Rabinowitz D,Lallone RL,Burley SK,Friedman JM. Weight reducing effects of theplasma protein encoded by the obese gene. Science 1995; 269:543-6.
Montague CT, Farooqi IS, Whitehead JP,Soos MA,Rav H,WarehamWJ et al. Congenital leptin deficiency is associated with severe early-onset obesity in humans. Nature 1997; 387:903-8. 13.Caro JR,Sinja MK,Kolaczynski JW,Zhang PL,Cosindine RB. Leptin:The tale of an obesity gene. Diabetes 1996; 45:1455-61.
Lönnqvist F,Arner P,Nordfors L,Shalling M. Overexpression of theobese gene mRNA in human obesity. J Clin Invest 1995; 95:2986-8
Agata J.,Masuda A,Takada M,Higashiura K,Murakami H,MiyazakiY,Shimamoto K.High plasma inunoreactive leptin level in essential hy-pertension. Am J. Hypertens 1997; 10:117-4
Bray G, York D. Leptin and clinical medicine.A new piece in the puzz-le of obesity. J. Clin Endocrinol Metab 1997; 82:27771-6
Dagogo—Jack,S. Fanelli C,Parmore D,Brothers J,Landt M,. PalsmaLeptin and Insulin relationships in Obese and Nonobese Humans ,Dia-betes 1996 :45:695-98
Blum,WF,Englaro P,Hanitsch S, Juul A,Hertel NT,Muller J,Skakke-baek NE,et al. Plasma leptin in Healthy Children and Adolescent:De-pendence on Body Mas Index,bode Fat,Pubertal Stage and Testostero-ne. J Clin. Endocr and Metab 1997; 83:2904
de Courten M,Zimmet P,HodgeA,Collins V,Nicolson M,Staten M,et al . Hyperleptinemia:the missing link in the metabolic syndrome?Diabet Med 1997;14:200-8
Rainwater DL,Comuzzie AG, VandeBerg J,Mahney MC,Blangero J.Serum leptin levels are independently correlated with two measures ofHDL. Atherosclerosis 1997; 132:237-43
Auwerx J,Staels B. Leptin. Lancet 1998; 351:737-42
Ambrosius WT; Compton JA; Bowsher RR; Pratt JH,Relation of race,age,and sex hormone differences to serum leptin concentrations in chil-dren and adolescents Horm Res 1998;49(5):240-6
Clayton PE,Gill MS,Hall CM,Tillmann V, WhatmoreAJ,Price DA,Serum leptin through childhood and adolescence,Clin Endocrinol1997;46(6):727-33
Zhang J,Gao Y,Guo X,Dong A. . The changes in plasma letpin,insu-lin and proinsulin levels in obese adolescents Zhonghua Nei Ke Za Zhi2002 41(4):221-3
Considine R,Sinha M,Heiman M,Kriacinus A,Stephens T,Nyce M,et al,Seum Immunoreactive concentrations in normal weight and obe-se humans,N Engl J Med 1996,334 (5) :292-293
Valle M,Gascon F,Maros R,Ruz FJ,Bermudo F,Morales R,CaneteR. Metabolic cardiovascular syndrome in obese prepubertral children;the role of high fasting insulin levels. Metabolismo 2002,,51(4):423-8
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