Detección del receptor tipo 2 del factor de crecimiento epidérmico humano (her2/neu)


  • José Luis Quirós Alpízar Universidad de Costa Rica
  • Isabel Arce Jiménez Universidad de Costa Rica
  • Gabriel Torrealba Acosta Universidad de Costa Rica
  • Ernesto Jiménez Montero Universidad de Costa Rica
  • Raquel Barrientos Cordero Universidad de Costa Rica


Palabras clave:

cáncer de mama, receptor tipo 2 del factor de crecimiento epidérmico humano (HER-2), inmunohistoquímica


Antecedentes: la incidencia y mortalidad por cáncer de mama han presentado un aumento neto. Uno de los tipos de esta heterogénea enfermedad se caracteriza por la amplificación y alta expresión del gen ERBB2, que codifica el receptor tipo 2 del factor de crecimiento epidérmico humano (HER2). Este receptor estimula procesos oncogénicos y dichos tumores se asocian a un peor pronóstico. El objetivo del estudio fue analizar las características de tumores HER-2+ en un grupo de pacientes con carcinoma de mama.

Métodos: se estudió los casos de mujeres con biopsia diagnóstica de cáncer de mama registrados durante 2006 en los archivos del Servicio de Anatomía Patológica del Hospital San Juan de Dios; entre los que contaban con estudios inmunohistoquímicos, se estudió la expresión de HER-2 y se realizó análisis estadísticos.

Resultados: se halló 34 tumores HER-2+ (15,7%), 24 con expresión fuerte (11,1%) y 10 con débil (4,6%). La edad media al diagnóstico de las pacientes con expresión fuerte fue de 46,9 años (42,5-51,1 IC 95%), y con expresión débil fue de 54,4 años (46,7-62,1 IC 95%); la edad promedio para los tumores HER-2- fue de 58,1 años (56,2-60,0 IC 95%). Las pacientes <50 años tuvieron un OR=3,477 de tener HER-2+. De 21 tumores, el 90,5% presentó un grado histológico alto, y de 16 casos, únicamente 3 tenían un tamaño <2 cm.

Conclusión: se encontró una asociación del tipo HER-2+ con pacientes jóvenes, tumores de mayor tamaño y alto grado histológico. Los datos encontrados en este primer reporte son similares a las últimas estimaciones mundiales.


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2015-01-30 — Actualizado el 2015-01-30


Cómo citar

Alpízar, J. L. Q., Jiménez, I. A., Acosta, G. T., Montero, E. J., & Cordero, R. B. (2015). Detección del receptor tipo 2 del factor de crecimiento epidérmico humano (her2/neu). Acta Médica Costarricense, 57(1), 23–28.