Tipificación molecular de los antígenos leucocitarios humanos, Estado del arte y perspectivas para los transplantes de células madre en Costa Rica

Autores/as

  • Esteban Arrieta Bolaños Universidad de Costa Rica
  • Lizbeth Salazar Sánchez Universidad de Costa Rica

DOI:

https://doi.org/10.51481/amc.v52i1.545

Palabras clave:

antígenos HLA, prueba de histocompatibilidad, células madre hematopoyéticas, bancos de donantes, Costa Rica

Resumen

El sistema de antígenos leucocitarios (Human Leukocyte Antigen) es el más polimórfico en el ser humano. Su función la realiza regulando la respuesta inmune mediante su unión a moléculas como el receptor de células T, participando en la presentación de antígenos y el reconocimiento de lo propio en el organismo. Su papel central en la respuesta inmune así como su polimorfismo convierten a estos genes en un factor fundamental en la terapia con trasplantes, siendo su importancia máxima en los trasplantes de células progenitoras hematopoyéticas. Consecuentemente, la tipificación de estos antígenos en los estudios de compatibilidad ha sido desarrollada de manera paralela y en las últimas décadas se ha avanzado grandemente en su comprensión y caracterización. Varias metodologías moleculares son las que predominan actualmente para la tipificación de los antígenos de histocompatibilidad leucocitarios. La información obtenida de estas caracterizaciones ha permitido la aparición de bancos de donantes de células madre y unidades de cordón umbilical, los cuales amplían la probabilidad de encontrar un donador compatible para el paciente. Los programas de trasplante de células madre hematopoyéticas en nuestro país requieren de un avance en las tecnologías disponibles para tipificación de estas moléculas, así como de la instauración de un registro nacional de donantes basado en su tipificación molecular. El presente trabajo tiene por objetivo presentar el estado del conocimiento actual sobre los antígenos leucocitarios humanos, su genética, su tipificación, sus utilidades y protocolos a seguir en la tecnología de los trasplantes de células madre.

Descargas

Los datos de descargas todavía no están disponibles.

Citas

Roitt I, Brostoff J, Male D. Immunology. 6th Ed. México: Mosby, 2001.

Choo SY. The HLA system: genetics, immunology, clinical testing, and clinical implications. Yonsei Med J. 2007; 48:11-23.

Reisner EG Human leukocyte and platelet antigens. en Beutler E, Lichtman MA, Coller BS, Kipps TJ editores. Williams Haematology. 5th ed México: McGraw-Hill Inc, 1995: 1611-17.

Contreras M, Lubenko A Antigens in human Blood. en Hoffbrand AV, Lewis SM editors. Postgraduate Haematology. 3rd ed. Butterworth Heinemann, 1992: 261-5.

Yan WH, Lin AF. Current opinion on human leukocyte antigen-G in China. Chin Med J (Engl). 2007; 120:1260-5.

Anthony Nolan Research Institute. En http://www.anthonynolan.org. uk/research/hlainformaticsgroup/. Recuperado el 5 de febrero de 2009.

Ji Y, Sun JL, Du KM, Xie JH, Ji YH, Yang JH, et al. Identification of a novel HLA-A*0278 allele in a Chinese family. Tissue Antigens. 2005;65:564-6.

Tang TF, Hou L, Tu B, Hwang WY, Yeoh AE, Ng J, et al. Identification of nine new HLA class I alleles in volunteers from the Singapore stem cell donor registries. Tissue Antigens. 2006;68:518-20.

Kanga U, Panigrahi A, Kumar S, Mehra NK. Asian Indian donor marrow registry: All India Institute of Medical Sciences experience. Transplant Proc. 2007; 39:719-20.

Abdeen H, McErlean C, Moraes ME, Torres M, Campiotto S, Galvão S, et al. Identification of three novel alleles of HLA-DRB1 and HLAA in the Brazilian population. Tissue Antigens. 2007;69:607-10.

Madrigal A, Shaw BE. Immunogenetic factors in donors and patients that affect the outcome of hematopoietic stem cell transplantation. Blood Cells Mol Dis. 2008; 40:40-3.

Rocha V, Labopin M, Sanz G, Arcese W, Schwerdtfeger R, Bosi A, et al. Acute Leukemia Working Party of European Blood and Marrow Transplant Group; Eurocord-Netcord Registry. Transplants of umbilical-cord blood or bone marrow from unrelated donors in adults with acute leukemia. N Engl J Med. 2004; 351:2276-85.

van der Helm-van Mil AHM, Verpoort KN, Breedveld FC, Huizinga TWJ, Toes REM, de Vries RRP. The HLA-DRB1 shared epitope alleles are primarily a risk factor for anti-cyclic citrullinated peptide antibodies and are not an independent risk factor for development of rheumatoid arthritis. Arthritis and Rheumatism. 2006; 54:1117-21.

Amirzargar AA, Khosravi F, Dianat SS, Alimoghadam K, Ghavamzadeh F, Ansaripour B, et al. Association of HLA class II allele and haplotype frequencies with chronic myelogenous leukemia and age-at-onset of the disease. Pathol Oncol Res. 2007; 13:47-51.

Flomenberg N, Baxter-Lowe LA, Confer D, Fernandez-Vina M, Filipovich A, Horowitz M, et al. Impact of HLA class I and class II high-resolution matching on outcomes of unrelated donor bone marrow transplantation: HLA-C mismatching is associated with a strong adverse effect on transplantation outcome. Blood. 2004; 104:1923-30.

Petersdorf E, Smith AG. High resolution donor HLA-matching: saving lives. CIBMTR Newsletter. 2006; 12:1-4.

Maury S, Balére-Appert ML, Chir Z, Boiron JM, Galambrun C, Yakouben K, et al. French Society of Bone Marrow Transplantation and Cellular Therapy (SFGM-TC). Unrelated stem cell transplantation for severe acquired aplastic anemia: improved outcome in the era of high-resolution HLA matching between donor and recipient. Hematologica. 2007; 92:589-96.

Lee SJ, Klein J, Haagenson M, Baxter-Lowe LA, Confer DL, Eapen M,et al. High-resolution donor-recipient HLA matching contributes to the success of unrelated donor marrow transplantation. Blood. 2007; 110:4576-83.

Petersdorf EW, Anasetti C, Martin PJ, Gooley T, Radich J, Malkki M, et al. Limits of HLA mismatching in unrelated hematopoietic cell transplantation. Blood. 2004; 104:2976-80.

Scott I, O'Shea J, Bunce M, Tiercy JM, Argüello JR, Firman H, et al. Molecular typing shows a high level of HLA class I incompatibility in serologically well matched donor/patient pairs: implications for unrelated bone marrow donor selection. Blood. 1998; 92:4864-71.

Prasad VK, Kernan NA, Heller G, O'Reilly RJ, Yang SY. DNA typing for HLA-A and HLA-B identifies disparities between patients and unrelated donors matched by HLA-A and HLA-B serology and HLADRB1. Blood. 1999; 93:399-409.

Shankarkumar U, Pawar A, Ghosh K. Implications of HLA sequencebased typing in transplantation. J Postgrad Med. 2008; 54:41-4.

Morishima Y, Sasazuki T, Inoko H, Juji T, Akaza T, Yamamoto K, et al. The clinical significance of human leukocyte antigen (HLA) allele compatibility in patients receiving a marrow transplant from serologically HLA-A, HLA-B, and HLA-DR matched unrelated donors. Blood. 2002; 99:4200-6.

Lee SJ, Klein J, Haagenson M, Baxter-Lowe LA, Confer DL, Eapen M, et al. High-resolution donor-recipient HLA matching contributes to the success of unrelated donor marrow transplantation. Blood. 2007; 110:4576-83.

Shaw BE, Marsh SG, Mayor NP, Russell NH, Madrigal JA. HLADPB1 matching status has significant implications for recipients of unrelated donor stem cell transplants. Blood. 2006; 107:1220-6.

Shaw BE, Gooley TA, Malkki M, Madrigal JA, Begovich AB, Horowitz MM, et al. The importance of HLA-DPB1 in unrelated donor hematopoietic cell transplantation. Blood. 2007; 110:4560-6.

Smith A. HLA Expression Variant Alleles. Question corner, ASHI Quarterly, 25(2), 2001.

Hurley CK, Baxter-Lowe LA, Logan B, Karanes C, Anasetti C, Weisdorf D, et al. National Marrow Donor Program HLA-matching guidelines for unrelated marrow transplants. Biol Blood Marrow Transplant. 2003; 9:610-5.

Kamani N, Spellman S, Hurley CK, Barker JN, Smith FO, Oudshoorn M, et al. National Marrow Donor Program. State of the art review: HLA matching and outcome of unrelated donor umbilical cord blood transplants. Biol Blood Marrow Transplant. 2008;14:1-6.

Liao C, Wu JY, Xu ZP, Li Y, Yang X, Chen JS, et al. Indiscernible benefit of high-resolution HLA typing in improving long-term clinical outcome of unrelated umbilical cord blood transplant. Bone Marrow Transplant. 2007; 40:201-8.

Petersdorf EW, Gooley T, Malkki M, Horowitz M; for The International Histocompatibility Working Group in Hematopoietic Cell Transplantation. Clinical significance of donor-recipient HLA matching on survival after myeloablative hematopoietic cell transplantation from unrelated donors. Tissue Antigens. 2007;69 (Suppl) 1:25-30.

Hurley CK, Maiers M, Marsh SG, Oudshoorn M. Overview of registries, HLA typing and diversity, and search algorithms. Tissue Antigens. 2007;69 (Suppl) 1:3-5.

Rojas Montero GM, Alvarez López MR, López Bermejo A, Moya Quiles MR, Muro Amador M. Descriptive study of activity of the bone marrow donor registry and bank from the Murcia Region (southeast of Spain) (1994-2004). An Med Interna. 2006; 23:525-8.

Bone Marrow Donors Worldwide. En http://www.bmdw.org/index.

php?id=number_donors0. Recuperado el 23 de junio de 2009.

Oudshoorn M, van Walraven SM, Bakker JN, Lie JL, V D Zanden HG, Heemskerk MB, et al. Hematopoietic stem cell donor selection: the Europdonor experience. Hum Immunol. 2006; 67:405-12.

Moraes JR, Alencar IS, Moraes ME, Pereira NF, Pasquini R, Tabak DG. Almost 50,000 volunteers participate at Redome, the Brazilian Bone Marrow Donor Registry. Transplant Proc. 2004; 36:814-5.

du Toit ED, Borrill V, Schlaphoff TE. The South African bone marrow registry (SABMR) in 2004. Transfus Apher Sci. 2005; 32:25-6.

Tiercy JM, Stadelmann S, Chapuis B, Gratwohl A, Schanz U, Seger RA, et al. Quality control of a national bone marrow donor registry: results of a pilot study and proposal for a standardized approach. Bone Marrow Transplant. 2003; 32:623-7.

Schmidt AH, Biesinger L, Baier D, Harf P, Rutt C. Aging of registered stem cell donors: implications for donor recruitment. Bone Marrow Transplant. 2008; 41: 605-12.

Vojvodić S, Popović SL. Predictive calculation of effectiveness of a regional bone marrow donor registry in Vojvodina, Serbia. Coll Antropol. 2007; 31: 579-86.

Kollman C, Abella E, Baitty RL, Beatty PG, Chakraborty R, Christiansen CL, et al. Assessment of optimal size and composition of the U.S. National Registry of hematopoietic stem cell donors.

Transplantation. 2004; 78:89-95.

Descargas

Publicado

2010-01-01

Cómo citar

Arrieta Bolaños, E., & Salazar Sánchez, L. (2010). Tipificación molecular de los antígenos leucocitarios humanos, Estado del arte y perspectivas para los transplantes de células madre en Costa Rica. Acta Médica Costarricense, 52(1), 8–15. https://doi.org/10.51481/amc.v52i1.545